Viser arkivet for stikkord aging

The case for Rejuvenation Biotechnology in 872 characters.

Growth stops at around age 25, after that decay is the sole changer of your body. Seven types of decay, one of them are akin to rust on cars. Rejuvenation biotechnology is to remove this rust after it has occurred, without having to know how the rust is made.
The case against rejuvenation biotechnology is often “but its good that people die of aging to make room for new people”. But is it good that the car rusts and eventually have to be scrapped in favor of a new car? Perhaps for you, but the car ends up being crushed into a cube, so its not a good thing for the car.
Similarly, aging and making room for the next generation is very bad for you, because you end up in a box-shape whether you want to or not.
Support Sens Research Foundation by clicking the bar at the top of the screen, and if you wish to know more, read the book Ending Aging by Aubrey de Grey, PhD.

Aging.

We learn nothing about aging in biology class until very specialized higher education degrees. And without knowledge, we have only emotions to base our opinions about aging on. What does our emotions make us think about the aging process? Usually, our emotions make us think that we can not do anything about aging. We have such negative emotions about aging that we convince ourselves that aging is a natural way of life, that we can not avoid aging no matter what we do. The reason we do this is because if we think we can avoid aging, then we would spend all our time trying to avoid aging, and no time reproducing. And if your parents spent all their time trying to avoid aging, you would not have been made. So you have inherited the idea that aging can not be avoided, from parents who are not educated in the biology of aging. That’s like inheriting a disease if you ask me.
We think aging can not be avoided without knowledge about how aging works, and the result is that we can continue our current way of life. We can continue to buy a new phone every six months, a new car every three years, and so on. But if we think we can avoid aging, then the rational thing to do would be to spend all resources otherwise spent on phones and cars, on avoiding aging. One would think this was not a high price to pay, after all its just stuff, and life is far more valuable. But our genes make us extremely interested in reproduction. And to males that mean having symbols of status and wealth. Cars, fancy clothes, phones, expensive wines, etc. And to females it means thinking a lot about male symbols of status and wealth, because it is a sign that the male can support children. So it is understandable that it is difficult to let go of the aquisition of wealth and status symbols in favor of trying to avoid dying of aging.
The reason why we easily conclude aging can not be avoided when we know nothing about aging, is that no one has avoided aging thus far in history. But we also consider aging a change that occurs in the body, not something that accumulates. We think of aging like growth, like going from a baby to an adult, and then to an old person. And we can’t imagine a way that can be reversed. Rightly so, making an adult person revert to a fetus is impossible. But this is not what aging is. Aging is not growing up from a fetus into an adult, and then into an old person. You grow up, from a single cell into adulthood, but what happens from there on in is just lack of maintenance. In a way, you come out of the womb as a small car which grows for 25 years to become a Hummer H1. But once you are 25 years old the change that occurs is just rust and poor maintenance. Its not growth, as in “growing old”. The H1 Hummer you are at 25 gets worn down for 55 years or so until you are 80 years old and need diapers. You as you were meant to be when you are 25. That you change from age 25 is a disease called aging. Growth happen until age 25 (approximately), decay happens from that point on. Aging is 7 things that we accumulate over time, starting from before we are born.

These are the 7 aspects of aging:
1. Cell loss or atrophy (without replacement).
2. Oncogenic nuclear mutations and epimutations (mutations in the cell nucleus (DNA), and mutations that affect how the DNA functions).
3. Cell senescence (Death-resistant cells and cells that no longer are able to replicate).
4. Mitochondrial mutations (the mitochondria grows shorter for every cell-division, fex).
5. Intracellular junk or junk inside cells (lysosomal aggregates).
6. Extracellular junk or junk outside cells (extracellular aggregates).
7. Random extracellular cross-linking.

These seven things accumulate over time. And for 25 years we show no sign of them. But then some skin cells begin showing signs of fex, accumulated oxidized cholesterol and a lack of mitochondrial length. The cells don’t replicate evenly, so they all replicate different amounts in 25 years. Some 50 times (the aproximate maximum), others zero times. And the junk inside the cells move mostly over to just one of the two cells when they divide, so after a dozen cell-divisions some cells will have lots of junk in them, and other cells will have no junk in them. When you are only 25 years old the amount of cells with lots of junk in them are few, but they are many enough to start to show on your skin. The first set of wrinkles appear. This is not growth, its decay due to lack of maintenance. This occurs in all the organs, we just can’t easily see the “wrinkles” there. For example the liver starts declining in function, and the liver is quite important, hence the name.

Support Sens Research Foundation who are working a treatment that removes 7-Ketocholesterol from the human body. 7-KC is one of those types of junk that accumulates in us. It is the main cause of cardiovascular disease. Click the bar at the top of the screen.
And read this book if you wish to have a detailed description of all seven aspects of aging and a possible strategy to fight each one, and if you wish to know how to contribute. The book is written for the none-scientist so its not hard to understand with lots of fancy words. Reading the book is the single greatest thing you can do for yourself, greater than buying a Ferrari, greater than climbing Mount Everest.

Healthcare queues.

Queues in healthcare is in the case of Norway, a sign of a healthy healthcare system. Increasing queues mean we are keeping people alive longer.
There is some confusion about how to deal with it in politics all over the world.

The healthcare system is like a dam, that slowly is filled with water from a river. Every year you have to spend X amount to keep the dam intact, and every year you must increase the size of the dam if you do not control how fast the water enters the dam. What you can do is this:
1. Decrease the amount of water that enters the dam.
2. Increase the size of the dam so it holds more water.
3. Increase the amount of water you release.
Translated to healthcare:
1. Increase research into the aging process.
2. Increase the amount of healthcare resources (beds, people etc).
3. Let more people die. This last one is obviously not an option.

For every person we put into making the dam bigger, we must put at minimum two people into decreasing the amount of water that fills the dam (rule of thumb, the real answer is a complex function).

In 2012 Norway spent 139 000 000 000 NOK keeping the dam intact. 3 000 000 000 NOK more to make the dam bigger from the previous year. But the increase in funding for stopping the dam filling up was in the millions, not billions. It is then not a surprise that the dam fills up even more, even faster, and next year we must add more billions to the dam to make it bigger.
Unless we do some serious effort into stopping the dam from filling up we will very quickly have to increase taxes for everyone, rich AND poor, and that will also just be temporary effect.
It will take a decade or two before we see any large scale benefit from research because a decade is about the time it takes to discover something new and make it into a medicine approved to be used on humans. So it is imperative that we do so right now, this instant. Because the longer we wait the more the queue will cost us, its like interest on interest.

At this point you no doubt think aging is a law of physics akin to “what goes up must come down”, but its not technically true, if you add energy to something you can have it fly continually, and never come down. Aging is chronic, you can’t remove it without changing pretty much everything, but you can treat it, you can “live with it”, as it were. You can never stop rust from occurring on a car without pretty much changing everything, but you CAN remove rust often enough for the car to never break down. Regularly fixing the damage Accumulated in the body as a result of the energy processes in the body.
If we had our bodies and brains in for regular service, lets say every decade or every other decade, then we would greatly decrease the cost of healthcare and live substantially longer (then with young capable bodies and brains, not old farts that can’t ski). But to do that we need research into how to do services on human bodies and brains, how to fix the rust, as it were.

Here is an example. They recently found out how to “do a service” so to speak, on mice, and by doing it they increased the lifespan of the mice by 24%, with just ONE service. Imagine if the services were done at regular intervals and pre-planned dates and times.
http://www.sciencedaily.com/releases/2012/05/120514204050.htm
This is what we should make the goal for everyone. The medical knowledge to be able to perform regular service on human bodies and brains so that we do not rust away like some crappy car no one bothers to restore. Services that regularly removes some of the molecular damage we accumulate from ionizing radiation, metabolic functions, DNA replication etc. Tell your friends and governments.

PostScript: Check the bar at the top of the page that says “Together we can end the diseases of aging. SENS Foundation”.

Aging and the European Convention on Human Rights.

Is underfunding of research into the aging process against the European Convention on Human Rights?

The European Convention on Human Rights reads as follows:
SECTION I
RIGHTS AND FREEDOMS ARTICLE 2
Right to life
1. Everyone’s right to life shall be protected by law. No one shall be deprived of his life intentionally save in the execution of a sentence of a court following his conviction of a crime for which this penalty is provided by law.

2. Deprivation of life shall not be regarded as inflicted in contravention of this Article when it results from the use of force which is no more than absolutely necessary:
(a) in defence of any person from unlawful violence;
(b) in order to effect a lawful arrest or to prevent the escape of a person lawfully detained;
( c ) in action lawfully taken for the purpose of quelling a riot or insurrection.

Age related disease daily deprive life from over 100 000 people worldwide.
http://en.wikipedia.org/wiki/List_of_causes_of_death_by_rate

Are these deaths caused intentionally by not funding research into the aging process? All the arguments against funding research on the aging process are irrelevant to this discussion, as they are not mentioned in the second part of Article 2 of ECHR.

Is life adequately protected by law? The law of most nations protect rather well against war, which only accounts for 0.3% of annual deaths in 2002. See list of causes by death by rate link. But the law of most nations protect extremely poorly against cardiovascular disease, infectious and parasitic diseases, ischemic heart disease, cancers and stroke, which account for 29.34%, 23.04%, 12.64%, 12.49% and 9.66% of annual deaths in 2002 respectively.

It could be relevant to this discussion that Article 13 reads:
Right to an effective remedy.
Everyone whose rights and freedoms as set forth in this Convention are violated shall have an effective remedy before a national authority notwithstanding that the violation has been committed by persons acting in an official capacity.

Here is the European Convention on Human Rights in its full, from the European Court of Human Rights website: http://www.echr.coe.int/NR/rdonlyres/D5CC24A7-DC13-4318-B457-5C9014916D7A/0/Convention_ENG.pdf

To summarise: Is life protected by law? Are people being deprived of life intentionally? (Intentional inaction/action)
What do you think?

This survey finds that 79% of Americans wish that life-extending treatments should be given to all who want them. This implies they also want us to develop life-extending treatments for those who want them.

Short about life-extending treatments: Aging is not to be mistaken as growth, they are two separate things that both change the body. But growth stops when the body is fully-grown (around 25 years for humans). At which point aging becomes the sole changing force of the body. Aging can be described as decay, like a boat that slowly fills with seawater due to imperfections in the hull. All you need to do to turn back aging a bit is to remove some of the seawater in the boat. It still fills slowly, but as long as you bail fast enough you can have a low chance of sinking for quite some time. There are only 7 types of decay. A guesstimate for how expensive it is to develop life extending treatments (that extend life substantially, by decades), puts it at around what the human genome project cost. So in todays money 5.5 billion NOK annually for 15-20 years. See the book Ending Aging by Aubrey de Grey, PhD, for a thorough walkthrough of strategies for how to develop these treatments. If you work in the Norwegian government, ask the Norwegian ministry of Health to borrow a copy, I have made sure they have eight. But really if those don’t work, its just a matter of trying other strategies. 5.5 billion Norwegian Kroners annually gets a lot of research. When the human genome project was started many experts did not think it was possible, because none of the technology they needed, existed. But today, 8 years after they had mapped the first human genome completely, a human genome can be read for only 35 000 NOK. Much of biotech research is done with computers and machines.

I think life is inadequately protected by law, and that inaction daily deprives 100 000 people who die of what we call “natural causes”. Article 2 does not add that people can be deprived of life from “natural causes” either. No doubt because certain states would argue that “natural causes” include a vast amount of unethical things.
Click the button at the top of this website that says “SENS Foundation”.

Irrational intelligence.

We are all irrational, no exceptions. What varies is how we are irrational, and what we are irrational about. Before we act rational despite [insert reason for not choosing the rational option], in every case, we can not call ourselves an intelligent species.

We smoke tobacco despite the fact that it will shorten our lives. We drive fast despite the fact that it will on average shorten our lives. We drink and eat unhealthily despite the fact that it will shorten our lives with as much as 40 years. We do not stop climate-change, despite the fact that it will kill humans. We do not map the asteroids and meteors in the solar-system despite the fact that asteroids and meteors hit earth every day and time and time again kills entire species. We do not put as much effort into curing disease as we are able to despite that disease kills 155 000 people a day. We do not care about long-term thinking despite it always biting us (see drought in USA, floods, deforestation, climate change etc, when it is not a problem we don’t care and when it becomes a problem we can only throw money at it to try to fix it, which rarely works). We do not donate as much processing-power as possible to medical research projects like folding@home and GPUgrid despite the fact that it will statistically extend our lives by atleast days no matter how bad your computer is. I could go on forever, but I am not rational enough to bother mentioning more examples despite the fact that it will extend my life to convince more people that reads this to install folding@home or BOINC programs to donate their computers processing-power to medical research. My irrational reason for not mentioning more examples is that I assume you will likely not be rational enough to do something that only shows clear return on investment half a century from now (because I too have problems sticking to only doing things that make me live a longer and healthier life than the alternative actions).